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Sample Quiz

Sample Quiz

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Question 1 of 5

1. Question
1 point(s)
P-glycoprotein is a
- drug transporter
- drug
- drug metabolizing enzyme
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Question 2 of 5

2. Question
1 point(s)
What is the function of PGP within the GI tract?
- It transports drugs from the enterocytes to the intestinal lumen
- It transports drugs from the capillaries into the enterocytes
- It transports drugs from the intestinal lumen into the enterocytes
- It transports drugs from the enterocytes to the capillaries
Correct

Incorrect
Question 3 of 5

3. Question
1 point(s)
When it comes to the blood brain barrier, what is the relevance (if any) of PGP?
- PGP actively effluxes drugs out of the brain and back into circulation
- PGP compromises the blood brain barrier by actively importing drugs into the brain
- PGP is not involved in the blood brain barrier
Correct

Incorrect
Question 4 of 5

4. Question
1 point(s)
What is the nature of clarithromycin-digoxin interaction involving PGP?
- Clarithromycin inhibits PGP, resulting in an increase in plasma digoxin concentration
- Clarithromycin inhibits PGP, resulting in a decrease in plasma digoxin concentration
- Clarithromycin induces PGP, resulting in an increase in plasma digoxin concentration
- Clarithromycin induces PGP, resulting in a decrease in plasma digoxin concentration
Correct

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Question 5 of 5

5. Question
1 point(s)
What is the role of PGP in cancer chemotherapy?
- Cancer cells that express PGP become resistant to chemotherapy because they efflux the drugs
- Cancer cells that express PGP become more sensitive to chemotherapy as they import the drugs
- PGP has no role here
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