- What are lipids?
- Free fatty acids (saturated, mono- & poly-unsaturated, omega FA)
- Triglycerides
- Phospholipids
- Glycolipids
- Sterols
- Fat soluble vitamins
- How are lipids absorbed and transported?
- Enterocyte absorption & reabsorption process
- Lipoprotein and albumin as carriers
- What are lipoproteins and how do they work?
- HDL, LDL, VLDL, Chylomicrons
- Assembly of lipoproteins
- Constituents of lipoproteins
- Lifecycles and functions of each lipoprotein
- What is dyslipidemia and what are the causes?
- Detailed description of cholesterol and triglyceride homeostasis
- Normal values for total cholesterol, triglycerides, LDL-C, HDL-C
- Calculation of LDL-C
- Description of specific defects that give rise to different types of dyslipidemias
- What is atherosclerosis?
- Atherosclerosis: relevance to coronary heart disease & stroke
- Stable vs. unstable atherosclerotic plaques
- Role of LDL and HDL in atherosclerosis
- Drugs for dyslipidemia:
- Sequestrants, Ezetimibe, Statins, Fibrates, Niacin, 3-Omega FA, Plant Sterols
- Relevant structural properties of selected drugs
- Dosing information when relevant
- Mechanistic basis for action
- Pharmacokinetic properties
- Adverse effects, contraindications, and drug-drug interactions
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