Learning Targets
- Learn definitions of frequently used terms in pharmacology
- Learn basis concepts in pharmacodynamics (eg. agonists, antagonists)
- Learn to interpret drug response curves (eg. Cmax, Kd, antagonism)
- Understand common signaling pathways involved in drug response (eg. GPCR, RTK)
- Learn basic pharmacokinetics:
- Absorption, bioavailability, first pass effect
- Distribution, plasma protein binding, volume of distribution
- Metabolism, biotransformation, Phase-I & Phase-II metabolism
- Elimination, renal and biliary
- Understand quantitative aspects of pharmacokinetics:
- Clearance
- Half-life
- Zero order and First order kinetics
- Continuous dosing & and multiple dosing kinetics
- Review basic toxicology:
- Immune toxicity, genotoxicity, neurotoxicity, mitochondrial toxicity
- Review basic concepts in pharmacogenetics & pharmacogenomics
- Variability in medicine (history)
- Polymorphisms (SNPs, haplotypes)
- Variability in pharmacokinetics & pharmacodynamics